Local tolerance and innate immune activation of primary human respiratory cells exposed to flagellin
Guy Barbin, Itziar Sanjuan-Garcia, Mireille Caul-Futy, Christine Caul-Futy, Cindia Ferreira Lopes, Rosy Bonfante, Édouard Sage, Anne‐Sophie Lacoste, Jean‐Michel Saliou, Delphine Cayet, Ronan J. MacLoughlin, Mara Baldry, Charlotte G Jensen, Arndt Benecke, Nathalie Heuzé‐Vourc'h, , Samuel Constant
This study evaluates the tolerance and innate immune response of human respiratory epithelial cells to FLAMOD, a flagellin-based therapy, showing dose-dependent activation of immune pathways without tissue damage.
bioRxiv · Dec 22, 2025 · PreprintCell Biology