Author

Édouard Sage

InsermORCID 0000-0001-7654-474XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Samuel ConstantiD· 2 shared Anne‐Sophie LacosteiD· 1 shared Arndt BeneckeiD· 1 shared Aude RémotiD· 1 shared Carole DrajaciD· 1 shared Cécile Ferret· 1 shared Charlotte G JenseniD· 1 shared Christine Caul-Futy· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

Samuel ConstantORCID

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2 papers

Recent·Most cited

Early-life exposure to commensal lung bacteria primes innate antiviral immunity and prevents RSV immunopathology in neonatal mice

Quentin Marquant, Claire Chottin, Cécile Ferret, Eloi Poucet, Vinciane Saint‐Criq, Daphné Laubreton, Carole Drajac, Edwige Bouguyon, Aude Rémot, Samuel Constant, Song Mei Huang, Édouard Sage, Isabelle Schwartz-Cornil, Muriel Thomas, Sabine Riffault, Delphyne Descamps

This study shows that early-life exposure to a specific lung bacterial strain reduces RSV immunopathology by enhancing antiviral immunity in neonatal mice and human airway models.

bioRxiv · Jul 1, 2026 · PreprintImmunology

Local tolerance and innate immune activation of primary human respiratory cells exposed to flagellin

Guy Barbin, Itziar Sanjuan-Garcia, Mireille Caul-Futy, Christine Caul-Futy, Cindia Ferreira Lopes, Rosy Bonfante, Édouard Sage, Anne‐Sophie Lacoste, Jean‐Michel Saliou, Delphine Cayet, Ronan J. MacLoughlin, Mara Baldry, Charlotte G Jensen, Arndt Benecke, Nathalie Heuzé‐Vourc'h, , Samuel Constant

This study evaluates the tolerance and innate immune response of human respiratory epithelial cells to FLAMOD, a flagellin-based therapy, showing dose-dependent activation of immune pathways without tissue damage.

bioRxiv · Dec 22, 2025 · PreprintCell Biology