Samuel Constant

This paper uses third-harmonic generation microscopy to visualize and measure mucociliary transport in human airway epithelium models without staining or processing.

This study shows that early-life exposure to a specific lung bacterial strain reduces RSV immunopathology by enhancing antiviral immunity in neonatal mice and human airway models.

This study shows that a bovine-derived H5N1 virus replicates efficiently in human nasal epithelial cells at both 37°C and 33°C, with specific mutations enhancing replication at lower temperatures.

This study uses human airway organoids to screen 764 natural plant extracts for antiviral activity against RSV, identifying 45 active compounds with distinct mechanisms.

This study evaluates the tolerance and innate immune response of human respiratory epithelial cells to FLAMOD, a flagellin-based therapy, showing dose-dependent activation of immune pathways without tissue damage.

This study shows flagellin activates TLR5 in human airway epithelium, enhancing immune responses in both healthy and diseased states, but not directly reducing bacterial load.

This study develops CD-SA, a β-cyclodextrin-based nanomaterial that acts as a potent broad-spectrum antiviral against influenza A and B viruses, showing higher efficacy than Oseltamivir in ex vivo and in vivo tests.

This paper evaluates a triple antiviral combination's efficacy against coronavirus in cell cultures and a hamster model, finding enhanced antiviral effects even with suboptimal doses.

This study evaluates a combined anti-influenza therapy using single cell RNA sequencing to show its effectiveness in inhibiting viral replication across different epithelial cell types.