Author

Guy C. Bedford

Rice University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1 Pathology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:ATAC-seq· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Isaac B. HiltoniD· 3 shared Alex J Ma· 1 shared Anael Roig-Gicquel· 1 shared Andrew R. DiNardoiD· 1 shared Barun MahataiD· 1 shared Daniel Reed· 1 shared Derek L. Yang· 1 shared Devika DuaiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMolecular Biology

Isaac B. HiltonORCID

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Author profile →

3 papers

Recent·Most cited

Induction of hysteretic chromatin states by CRISPRa reveals locus-specific encoding of transcriptional memory

Guy C. Bedford, Sangrok Han, Derek L. Yang, Devika Dua, Hakeem Shitta-Bey, Michael A. Beauregard, Andrew R. DiNardo, Isaac B. Hilton, Michael R. Diehl

The paper uses CRISPRa to show that transcriptional memory can be induced in MSCs through locus-specific activation, linked to H3K27me3 loss and increased transcription factor reacquisition.

bioRxiv · Sep 30, 2026 · PreprintMolecular Biology

Loss of Syndecan-3 Drives a Pro-inflammatory, EndMT-prone Phenotype in Aortic Valve Endothelial Cells

George I. Ezeokeke, Guy C. Bedford, Joseph JC Stroschein, Anael Roig-Gicquel, Isaac B. Hilton, Kathryn Jane Grande-Allen

This study identifies syndecan-3 as a regulator of inflammation and EndMT in aortic valve endothelial cells, showing its role in suppressing NF-kappaB activation and mesenchymal transition.

bioRxiv · Sep 8, 2026 · PreprintPathology

Tailoring a CRISPR/Cas-based Epi-editor for Decreased Cytotoxicity and Enzymatic Specificity

Jacob Goell, Jing Li, Barun Mahata, Alex J Ma, Sunghwan Kim, Spencer T. Shah, Shriya Shah, Maria Contreras, Suchir Misra, Daniel Reed, Guy C. Bedford, Mario Escobar, Isaac B. Hilton

This paper engineers modified p300 variants fused to dCas9 to reduce cytotoxicity and enhance enzymatic specificity in CRISPR-based epi-editing.

bioRxiv · Sep 22, 2024 · PreprintSynthetic Biology