Author

Jacob Goell

Boston UniversityORCID 0000-0002-6554-8769Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Isaac B. HiltoniD· 2 shared Alan CabreraiD· 1 shared Alex J Ma· 1 shared Barun MahataiD· 1 shared Daniel Reed· 1 shared Guy C. Bedford· 1 shared Jeffrey P. SpenceiD· 1 shared Jing LiiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBioinformatics

Isaac B. HiltonORCID

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2 papers

Recent·Most cited

Predicting the effect of CRISPR-Cas9-based epigenome editing

Sanjit Singh Batra, Alan Cabrera, Jeffrey P. Spence, Jacob Goell, Selvalakshmi S Anand, Isaac B. Hilton, Yun S Song

The paper trains machine learning models to predict gene expression from histone PTMs using ENCODE data and validates predictions with CRISPR-Cas9-based epigenome editing experiments.

eLife · Jan 12, 2026Peer-reviewedBioinformatics

Tailoring a CRISPR/Cas-based Epi-editor for Decreased Cytotoxicity and Enzymatic Specificity

Jacob Goell, Jing Li, Barun Mahata, Alex J Ma, Sunghwan Kim, Spencer T. Shah, Shriya Shah, Maria Contreras, Suchir Misra, Daniel Reed, Guy C. Bedford, Mario Escobar, Isaac B. Hilton

This paper engineers modified p300 variants fused to dCas9 to reduce cytotoxicity and enhance enzymatic specificity in CRISPR-based epi-editing.

bioRxiv · Sep 22, 2024 · PreprintSynthetic Biology