ImmTACs overcome cytotoxic T cell suppression
Lan Huynh, Abdullah Aljohani, Amal Alsubaiti, Tressan Grant, Alexandra Chapman, Gwilym Phillips, Jonathan M. G. Chamberlain, Alice Hayward-Wills, Ute Jungwirth, Mariolina Salio, Christopher J. Holland, Christoph Wülfing
This study investigates how ImmTACs activate suppressed cytotoxic T cells, finding they can induce cytolysis but not IFN-gamma secretion, and enhance CTL polarization and calcium signaling.
Immunotherapy Advances · Dec 31, 2025Peer-reviewedImmunology