Author

Christopher J. Holland

Immunocore (United Kingdom)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Assay:flow cytometry· 1

Frequent Co-Authors

Abdullah Aljohani· 2 shared Amal Alsubaiti· 2 shared Christoph WülfingiD· 2 shared Lan Huynh· 2 shared Tressan GrantiD· 2 shared Alexandra Chapman· 1 shared Alice Hayward-Wills· 1 shared Andrew Herman· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

Abdullah Aljohani

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

ImmTACs overcome cytotoxic T cell suppression

Lan Huynh, Abdullah Aljohani, Amal Alsubaiti, Tressan Grant, Alexandra Chapman, Gwilym Phillips, Jonathan M. G. Chamberlain, Alice Hayward-Wills, Ute Jungwirth, Mariolina Salio, Christopher J. Holland, Christoph Wülfing

This study investigates how ImmTACs activate suppressed cytotoxic T cells, finding they can induce cytolysis but not IFN-gamma secretion, and enhance CTL polarization and calcium signaling.

Immunotherapy Advances · Dec 31, 2025Peer-reviewedImmunology

Interaction with tumor cell spheroids induces suppression in primary human cytotoxic T cells

Amal Alsubaiti, Hanin Alamir, Lan Huynh, Tressan Grant, Abdullah Aljohani, Po Han Chou, Yiwei Shi, Maryam Alismail, Lydia R Mason, Andrew Herman, John S. Bridgeman, Christopher J. Holland, Christoph Wülfing

The paper generates and characterizes primary human cytotoxic T cells with suppressed function in vitro, showing their resemblance to exhausted tumor-infiltrating CTL and identifying factors affecting their effector function.

Immunotherapy Advances · Dec 30, 2024Peer-reviewedImmunology