The small molecule KHS101 induces bioenergetic dysfunction in glioblastoma cells through inhibition of mitochondrial HSPD1
E. S. Polson, V. B. Kuchler, C. Abbosh, E. M. Ross, R. K. Mathew, H. A. Beard, E. Chuntharpursat-Bon, J. Williams, B. Da Silva, H. Shao, A. Patel, A. J. Davies, A. Droop, H. B. S. Griffiths, P. Chumas, , H. Wurdak
The paper shows KHS101 inhibits HSPD1 in glioblastoma cells, causing metabolic dysfunction and tumor growth reduction without affecting normal cells.
bioRxiv · Oct 18, 2017Cancer Biology