Author

H. Wurdak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 7 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 8 Assay:bulk RNA-seq· 6 Approach:experimental assay· 5 Research Focus:cancer & tumor microenvironment· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:cell signaling & trafficking· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

R. K. Mathew· 4 shared S. C. Short· 4 shared A. Droop· 3 shared B. da Silva· 3 shared B. K. Irving· 2 shared E. Polson· 2 shared E. S. Polson· 2 shared J. Williams· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersCancer Biology

R. K. Mathew

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Identification of genes with oscillatory expression in glioblastoma: The paradigm of SOX2

R. Z. Fu, O. Cottrell, L. Cutillo, A. Rowntree, Z. Zador, H. Wurdak, N. Papalopulu, E. Marinopoulou

The paper identifies oscillatory genes in glioblastoma, including SOX2, which oscillates in quiescent glioblastoma stem cells, suggesting new regulatory roles in quiescence.

bioRxiv · Nov 12, 2023 · PreprintCancer Biology

Metabolic breakdown of non-small cell lung cancers by mitochondrial HSPD1 targeting

B. Parma, V. Ramesh, P. N. Gollavilli, A. M. Siddiqui, L. Pinna, A. Schwab, S. Marshall, S. Zhang, C. Pilarsky, F. Napoli, M. Volante, S. Urbanczyk, D. Mielenz, H. D. Schroeder, M. Stemmler, , P. Ceppi

This study identifies HSPD1 as a therapeutic target in NSCLC, showing its disruption leads to metabolic breakdown and suppressed tumor growth.

bioRxiv · Mar 9, 2021Cancer Biology

TGF-beta promotes microtube formation in glioblastoma through Thrombospondin 1

J. V. Joseph, C. R. Magaut, S. Storevik, L. H. Geraldo, T. Mathivet, A. M. Latif, J. Rudewicz, J. Guyon, M. Gambaretti, F. Haukas, A. Trones, L. A. R. Ystaas, J. A. Hossain, S. Ninzima, W. Zhou, , H. Miletic

This study identifies TGF-beta and TSP1 as key drivers of microtube formation in glioblastoma, showing their role in invasion and treatment resistance.

bioRxiv · Feb 22, 2021Cancer Biology

The cell cycle state defines TACC3 as a regulator gene in glioblastoma

H. Briggs, E. Polson, B. K. Irving, A. Zougman, R. K. Mathew, D. M. Gendoo, H. Wurdak

The paper identifies TACC3-dependent genes that correlate with poor survival in glioblastoma patients, revealing its role in cell cycle-regulated gene networks.

bioRxiv · Oct 20, 2020 · PreprintCancer Biology

Expression profiling of single cells and patient cohorts identifies multiple immunosuppressive pathways and an altered natural killer cell phenotype in glioblastoma

H. J. Close, L. F. Stead, J. Nsengimana, K. Reilly, A. Droop, H. Wurdak, R. K. Mathew, R. Corns, J. A. Newton-Bishop, A. A. Melcher, S. C. Short, G. P. Cook, E. B. Wilson

bioRxiv · Oct 4, 2019Immunology

A high-content screen profiles cytotoxic microRNAs in pediatric and adult glioblastoma cells and identifies miR-1300 as a potent inducer of cytokinesis failure

M. Boissinot, H. King, M. Adams, J. Higgins, T. A. Ward, L. P. Steele, D. Tams, R. Morton, E. Polson, B. da Silva, A. P. Droop, J. L. Hayes, H. Martin, P. Laslo, E. E. Morrison, , S. C. Short

This study identifies miR-1300 as a potent cytotoxic microRNA in glioblastoma cells, causing cytokinesis failure and apoptosis, with potential therapeutic applications.

bioRxiv · Oct 1, 2019 · PreprintCancer Biology

Chemically-induced Neurite-like Outgrowth Reveals Multicellular Network Function in Patient-derived Glioblastoma Cells

B. da Silva, E. S. Polson, A. Droop, R. K. Mathew, L. F. Stead, J. Williams, S. C. Short, M. Scarcia, G. Mavria, H. Wurdak

The paper shows that ROCKi promotes neurite-like outgrowth in GBM cells, forming radiation-resistant multicellular networks that can be reversed.

bioRxiv · Nov 10, 2018Cancer Biology

The small molecule KHS101 induces bioenergetic dysfunction in glioblastoma cells through inhibition of mitochondrial HSPD1

E. S. Polson, V. B. Kuchler, C. Abbosh, E. M. Ross, R. K. Mathew, H. A. Beard, E. Chuntharpursat-Bon, J. Williams, B. Da Silva, H. Shao, A. Patel, A. J. Davies, A. Droop, H. B. S. Griffiths, P. Chumas, , H. Wurdak

The paper shows KHS101 inhibits HSPD1 in glioblastoma cells, causing metabolic dysfunction and tumor growth reduction without affecting normal cells.

bioRxiv · Oct 18, 2017Cancer Biology