Author

A. Droop

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Genetic & Genomic Medicine· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Assay:bulk RNA-seq· 4 Research Focus:differential expression· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

L. F. Stead· 4 shared S. C. Short· 4 shared H. Wurdak· 3 shared R. K. Mathew· 3 shared A. Brodbelt· 2 shared A. Bruning-Richardson· 2 shared A. Chakrabarty· 2 shared A. Ismail· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersCancer Biology

L. F. Stead

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy

G. Tanner, R. Barrow, M. Finetti, S. Ajaib, N. Ahmed, S. Pollock, N. Rippaus, A. F. Bruns, K. Syed, J. Poulter, E. A. Wilson, C. A. Johnson, F. S. Varn, A. Bruning-Richardson, C. Hogg, , L. F. Stead

This study identifies two IDHwt glioblastoma subtypes based on transcriptional response to treatment, with distinct resistance mechanisms and potential therapeutic implications.

bioRxiv · Feb 3, 2023Cancer Biology

Fine-mapping of melanoma-associated genomic regions identifies novel causal SNPs in the MTAP/CDKN2A and CASP8 loci

C. Castaneda-Garcia, V. Iyer, J. Nsengimana, A. Trower, A. Droop, K. M. Brown, J. Choi, T. Zhang, M. Harland, J. A. Newton-Bishop, D. T. Bishop, D. J. Adams, M. M. Iles, C. D. Robles-Espinoza

The paper fine-maps melanoma-associated genomic regions to identify novel causal SNPs in the MTAP/CDKN2A and CASP8 loci using sequencing, variant filtering, and functional assays.

medRxiv · Jul 17, 2021 · PreprintGenetic & Genomic Medicine

Expression profiling of single cells and patient cohorts identifies multiple immunosuppressive pathways and an altered natural killer cell phenotype in glioblastoma

H. J. Close, L. F. Stead, J. Nsengimana, K. Reilly, A. Droop, H. Wurdak, R. K. Mathew, R. Corns, J. A. Newton-Bishop, A. A. Melcher, S. C. Short, G. P. Cook, E. B. Wilson

bioRxiv · Oct 4, 2019Immunology

JARID2 facilitates transcriptional reprogramming in glioblastoma in response to standard treatment

N. Rippaus, A. F-Bruns, G. Tanner, C. Taylor, A. Droop, A. Bruning-Richardson, M. A. Care, J. Wilkinson, M. D. Jenkinson, A. Brodbelt, A. Chakrabarty, A. Ismail, S. C. Short, L. F. Stead

The paper identifies JARID2-mediated transcriptional reprogramming in glioblastoma post-treatment, showing dysregulated genes with JARID2 binding sites are universally altered in recurrent tumors.

bioRxiv · Jun 17, 2019 · PreprintCancer Biology

Chemically-induced Neurite-like Outgrowth Reveals Multicellular Network Function in Patient-derived Glioblastoma Cells

B. da Silva, E. S. Polson, A. Droop, R. K. Mathew, L. F. Stead, J. Williams, S. C. Short, M. Scarcia, G. Mavria, H. Wurdak

The paper shows that ROCKi promotes neurite-like outgrowth in GBM cells, forming radiation-resistant multicellular networks that can be reversed.

bioRxiv · Nov 10, 2018Cancer Biology

The small molecule KHS101 induces bioenergetic dysfunction in glioblastoma cells through inhibition of mitochondrial HSPD1

E. S. Polson, V. B. Kuchler, C. Abbosh, E. M. Ross, R. K. Mathew, H. A. Beard, E. Chuntharpursat-Bon, J. Williams, B. Da Silva, H. Shao, A. Patel, A. J. Davies, A. Droop, H. B. S. Griffiths, P. Chumas, , H. Wurdak

The paper shows KHS101 inhibits HSPD1 in glioblastoma cells, causing metabolic dysfunction and tumor growth reduction without affecting normal cells.

bioRxiv · Oct 18, 2017Cancer Biology