Author

H. A. Kestler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

A. Sahm· 2 shared M. Bens· 2 shared M. Groth· 2 shared M. Platzer· 2 shared A. Cellerino· 1 shared C. Calkhoven· 1 shared C. Englert· 1 shared C. Mueller· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersEvolutionary Biology

A. Sahm

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2 papers

Recent·Most cited

Non-aging despite high mutation rate - genomic insights into the evolution of Hydra

A. Sahm, K. Riege, M. Groth, M. Bens, J. M. Kraus, M. Fischer, H. A. Kestler, C. Englert, R. Schaible, M. Platzer, S. Hoffmann

This study examines Hydra's genome to understand its non-aging phenotype, finding no reduced mutation rate and identifying genes under selection related to regeneration and metabolism.

bioRxiv · May 18, 2022 · PreprintEvolutionary Biology

Long-lived rodents reveal signatures of positive selection in genes associated with lifespan and eusociality

A. Sahm, M. Bens, K. Szafranski, S. Holtze, M. Groth, M. Goerlach, C. Calkhoven, C. Mueller, M. Schwab, H. A. Kestler, A. Cellerino, H. Burda, T. Hildebrandt, P. Dammann, M. Platzer

The paper identifies genes under positive selection in long-lived rodents, linking them to mTOR-related processes, immune function, and antioxidant defense, and finds expression patterns consistent with antagonistic pleiotropy in aging.

bioRxiv · Oct 8, 2017Evolutionary Biology