Author

M. Groth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Cancer Biology· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

M. Platzer· 3 shared A. Cellerino· 2 shared A. Sahm· 2 shared H. A. Kestler· 2 shared M. Bens· 2 shared A. B. Heckmann· 1 shared A. Salamero-Boix· 1 shared A. Schaeffer· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersEvolutionary Biology

M. Platzer

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

RPG interacts with E3-ligase CERBERUS to mediate rhizobial infection in Lotus japonicus

X. Li, M. Liu, M. Cai, D. Chiasson, M. Groth, A. B. Heckmann, T. L. Wang, M. Parniske, J. A. Downie, F. Xie

The paper identifies RPG as required for infection thread formation in Lotus japonicus and shows it interacts with CERBERUS to mediate polarity growth driven by nuclear migration.

bioRxiv · Jun 30, 2022Cell Biology

Non-aging despite high mutation rate - genomic insights into the evolution of Hydra

A. Sahm, K. Riege, M. Groth, M. Bens, J. M. Kraus, M. Fischer, H. A. Kestler, C. Englert, R. Schaible, M. Platzer, S. Hoffmann

This study examines Hydra's genome to understand its non-aging phenotype, finding no reduced mutation rate and identifying genes under selection related to regeneration and metabolism.

bioRxiv · May 18, 2022 · PreprintEvolutionary Biology

Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis

F. Klemm, A. Schaeffer, A. Salamero-Boix, T. Alekseeva, M. Schulz, K. Niesel, R. R. Maas, M. Groth, B. T. Elie, R. L. Bowman, M. E. Hegi, R. T. Daniel, P. S. Zeiner, J. Zinke, P. N. Harter, , L. Sevenich

The paper shows that blocking CSF1R in brain metastases initially reduces tumor growth but is ineffective in established tumors due to compensatory macrophage activation, which is overcome by combining CSF1R and STAT5 inhibition.

bioRxiv · Jun 7, 2021Cancer Biology

Mitohormetic effects of rotenone drastically depend on age

M. Baumgart, M. Ugolini, M. Groth, M. Platzer, A. Cellerino

This study investigates how the hormetic effects of rotenone on lifespan and transcriptome vary with age in a vertebrate species.

bioRxiv · Jan 23, 2019 · PreprintPharmacology & Toxicology

Long-lived rodents reveal signatures of positive selection in genes associated with lifespan and eusociality

A. Sahm, M. Bens, K. Szafranski, S. Holtze, M. Groth, M. Goerlach, C. Calkhoven, C. Mueller, M. Schwab, H. A. Kestler, A. Cellerino, H. Burda, T. Hildebrandt, P. Dammann, M. Platzer

The paper identifies genes under positive selection in long-lived rodents, linking them to mTOR-related processes, immune function, and antioxidant defense, and finds expression patterns consistent with antagonistic pleiotropy in aging.

bioRxiv · Oct 8, 2017Evolutionary Biology