G. J. Morgan

Abnormal global longitudinal strain and reduced serum inflammatory markers in cardiac AL amyloidosis patients without significant amyloid fibril deposition

The paper identifies early molecular and functional signatures in cardiac AL amyloidosis patients with abnormal GLS and reduced inflammatory markers despite no significant amyloid fibril deposition.

Characterization of an amyloidogenic intermediate of transthyretin by NMR relaxation dispersion

This study uses NMR relaxation dispersion to characterize the structural dynamics of an amyloidogenic intermediate of transthyretin, revealing conformational fluctuations that promote amyloid formation.

Kinetic evidence for multiple aggregation pathways in antibody light chain variable domains

This study investigates the kinetic behavior of antibody light chain variable domain aggregation, finding non-linear concentration dependence and multiple aggregation pathways.

The Vk*MYC Mouse Model recapitulates human multiple myeloma evolution and genomic diversity

The paper develops a Vk*MYC mouse model of multiple myeloma that mirrors human disease progression, genomic diversity, and key molecular features.

An amyloidosis-associated polymorphism does not alter LECT2 stability in vitro

This study investigates whether a valine-to-isoleucine polymorphism in LECT2 affects protein stability and aggregation, finding no consistent difference between variants.

Genetic Subtypes of Smoldering Multiple Myeloma are associated with Distinct Pathogenic Phenotypes and Clinical Outcomes

This study identifies six genetic subtypes of smoldering multiple myeloma associated with distinct clinical outcomes and progression risks.

Integrative multi-omics identifies high risk Multiple Myeloma segment associated with significant DNA loss and dysregulated DNA repair and cell cycle pathways

The paper identifies a high-risk Multiple Myeloma subgroup using multi-omics data, linking genomic loss to dysregulated DNA repair and cell cycle pathways.

Microhomology-mediated end joining drives complex rearrangements and over expression of MYC and PVT1 in multiple myeloma

The paper identifies MYC rearrangements in multiple myeloma, showing they are complex and linked to overexpression of MYC and PVT1 through distinct DNA repair mechanisms.

Translation efficiency is maintained at elevated temperature in E. coli

The paper investigates how translation efficiency in E. coli remains stable under heat shock and finds that mRNA structure and cotranslational translocation influence this stability.