Author

H. D. McMillan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

P. D. Mace· 2 shared A. D. Axtman· 1 shared A. Dunbier· 1 shared A. E. Burgess· 1 shared A. K. Dunbier· 1 shared E. K. Papachristou· 1 shared J. Carroll· 1 shared J. Hazlett· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

P. D. Mace

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Author profile →

2 papers

Recent·Most cited

TRIB1 modulates transcriptional programming in breast cancer cells to regulate cell proliferation

H. D. McMillan, E. K. Papachristou, J. Hazlett, S. Omarjee, J. Carroll, M. Black, P. D. Mace, A. Dunbier

This study shows TRIB1 promotes breast cancer cell proliferation by regulating MYC expression and cell cycle progression through interactions with β-catenin and ER-driven transcription.

bioRxiv · Jul 6, 2023 · PreprintCancer Biology

Substrate binding allosterically relieves autoinhibition of the TRIB1 pseudokinase

S. A. Jamieson, Z. Ruan, A. E. Burgess, J. R. Curry, H. D. McMillan, J. L. Brewster, A. K. Dunbier, A. D. Axtman, K. Natarajan, P. D. Mace

The paper shows that substrate binding to TRIB1 pseudokinase induces allosteric changes enabling complex formation with COP1 ubiquitin ligase.

bioRxiv · May 3, 2018Biochemistry