Z. Ruan

Effect of Sulfate Availability on Phytoplankton Stoichiometry

This study examines how sulfate availability affects phytoplankton elemental stoichiometry, finding that red lineage species have higher sulfur content and distinct responses to sulfate changes compared to green lineage species.

A Novel Liver Cancer-Selective Histone Deacetylase Inhibitor Is Effective Against Hepatocellular Carcinoma and Induces Durable Responses with Immunotherapy

This paper identifies a novel HDAC inhibitor, STR-V-53, that effectively targets HCC and enhances immunotherapy responses in mouse models.

Molecular mechanism of NAD+ binding to the Nudix homology domains of DBC1

This study investigates how NAD+ binds to DBC1's Nudix homology domains using NMR, ITC, and molecular docking, revealing key residues and binding affinity.

Liver fibrosis uncouples tumor control from survival after multikinase inhibitor immunotherapy in hepatocellular carcinoma

Liver fibrosis limits the survival benefit of multikinase inhibitor immunotherapy in hepatocellular carcinoma by promoting innate immune-mediated hepatotoxicity despite preserved tumor control.

Human Pannexin 1 Channel is NOT Phosphorylated by Src Tyrosine Kinase at Tyr199 and Tyr309

This study shows that commercially available antibodies for detecting PANX1 tyrosine phosphorylation are nonspecific and that Src does not phosphorylate these sites in heterologous systems.

Vgamma9Vdelta2 T cells recognize butyrophilin 2A1 and 3A1 heteromers

The paper reveals that Vgamma9Vdelta2 T cells recognize BTN2A1 and BTN3A1 heteromers through dual epitope engagement, uncovering a new mechanism of immune activation.

Reprogramming Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy

This paper shows that combining chemotherapy with CTLA-4 blockade reprograms the immune microenvironment of intrahepatic cholangiocarcinoma, enhancing the effectiveness of anti-PD1 therapy.

Molecular mechanism underlying desensitization of the proton-activated chloride channel PAC

This study identifies key residues and structural interactions involved in pH-dependent desensitization of the proton-activated chloride (PAC) channel using electrophysiology, mutagenesis, and molecular dynamics simulations.

Inflammasome targeting with an NLRP3 agonist therapy is feasible but ineffective in murine hepatocellular carcinoma models with liver damage

This study tests an NLRP3 agonist added to PD-1/VEGFR inhibitors in murine HCC models with liver damage, finding it feasible but ineffective in improving tumor outcomes.

Structures of TRPM5 channel elucidate mechanism of activation and inhibition

This paper reports cryo-EM structures of TRPM5 channels in different states, revealing mechanisms of activation and inhibition through ligand binding sites.

Embedded Enzyme Nanoclusters Depolymerize Polyesters via Chain-End Mediated Processive Degradation

This paper demonstrates that enzyme nanoclusters can depolymerize polyesters via chain-end mediated processive degradation, enabling scalable bioactive plastics for efficient sorting.

Identification of Adomavirus Virion Proteins

This paper identifies virion proteins of adomaviruses, linking them to adenoviruses and adintoviruses, and suggests a shared evolutionary history among small DNA tumor viruses.

Proteomic and Biological Profiling of Extracellular Vesicles from Alzheimer’s Disease Human Brain Tissues

The paper profiles proteomic and biological features of extracellular vesicles from Alzheimer’s disease and control brain tissues, identifying new signature proteins associated with AD.

LF4/MOK and a CDK-related kinase regulate the number and length of cilia in Tetrahymena

This study identifies LF4/MOK and CDKR1 as regulators of cilium length and number in Tetrahymena, showing LF4A inhibits intraflagellar transport and CDKR1 modulates LF4A activity.

Substrate binding allosterically relieves autoinhibition of the TRIB1 pseudokinase

The paper shows that substrate binding to TRIB1 pseudokinase induces allosteric changes enabling complex formation with COP1 ubiquitin ligase.