A combination of major histocompatibility complex (MHC) I overexpression and type I interferon induce mitochondrial dysfunction in human skeletal myoblasts.
A. Thoma, H. L. Bond, T. Akter-Miah, N. Al-Shanti, H. Degens, V. Pekovic-Vaughan, A. P. Lightfoot
This study shows that MHC-I overexpression and type I IFNs together worsen mitochondrial dysfunction in human skeletal myoblasts.
bioRxiv · Apr 10, 2024Cell Biology