Author

A. Thoma

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:metabolomics· 2 Organism:mouse· 2

Frequent Co-Authors

A. P. Lightfoot· 4 shared R. G. Cooper· 3 shared N. Al-Shanti· 2 shared G. Nye· 1 shared H. Degens· 1 shared H. L. Bond· 1 shared J. E. Parkes· 1 shared K. E. Earl· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersCell Biology

A. P. Lightfoot

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Author profile →

4 papers

Recent·Most cited

A combination of major histocompatibility complex (MHC) I overexpression and type I interferon induce mitochondrial dysfunction in human skeletal myoblasts.

A. Thoma, H. L. Bond, T. Akter-Miah, N. Al-Shanti, H. Degens, V. Pekovic-Vaughan, A. P. Lightfoot

This study shows that MHC-I overexpression and type I IFNs together worsen mitochondrial dysfunction in human skeletal myoblasts.

bioRxiv · Apr 10, 2024Cell Biology

Major Histocompatibility Complex (MHC) I-induced Endoplasmic Reticulum (ER) Stress mediates the secretion of pro-inflammatory muscle-derived cytokines

A. Thoma, K. E. Earl, R. G. Cooper, K. Goljanek-Whysall, A. P. Lightfoot

This study shows that MHC I overexpression in muscle cells induces ER stress, leading to pro-inflammatory cytokine release, which is reduced by salubrinal.

bioRxiv · Jun 29, 2022Cell Biology

Eukarion-134 attenuates endoplasmic reticulum stress-induced mitochondrial dysfunction in human skeletal muscle cells

A. Thoma, M. Lyon, N. Al-Shanti, G. Nye, R. G. Cooper, A. P. Lightfoot

This study shows that EUK-134 reduces ER stress-induced mitochondrial dysfunction in skeletal muscle cells by mitigating ROS generation and improving mitochondrial function.

bioRxiv · Jun 10, 2020Physiology

17-(Allylamino)-17demethoxygeldanamycin reduces Endoplasmic Reticulum (ER) stress-induced mitochondrial dysfunction in C2C12 myotubes

A. P. Lightfoot, R. S. Morgan, J. E. Parkes, A. Thoma, L. A. Iwanejko, R. G. Cooper

This study shows that 17AAG reduces ER stress-induced mitochondrial dysfunction and oxidative damage in C2C12 myotubes.

bioRxiv · Jun 19, 2018 · PreprintCell Biology