Author

H. Holstege

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

M. Hulsman· 2 shared A. M. G. Jensen· 1 shared D. de Jong· 1 shared E. B. van den Akker· 1 shared F. Baas· 1 shared F. J. Staal· 1 shared G. Monti· 1 shared J. G. Olsen· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

M. Hulsman

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Author profile →

2 papers

Recent·Most cited

Relying on the relationship with known disease-causing variants in homologous proteins to predict pathogenicity of SORL1 variants in Alzheimer's disease

O. M. Andersen, G. Monti, A. M. G. Jensen, M. de Waal, M. Hulsman, J. G. Olsen, H. Holstege

The paper predicts pathogenic SORL1 variants in Alzheimer's disease by analyzing homologous proteins with known disease-causing variants.

bioRxiv · Feb 27, 2023 · PreprintBiochemistry

DYNAMIC CLONAL HEMATOPOIESIS AND FUNCTIONAL T-CELL IMMUNITY IN A SUPER-CENTENARIAN

E. B. van den Akker, S. Makrodimitris, M. Hulsman, M. H. Brugman, T. Nikolic, T. Bradley, Q. Waisfisz, F. Baas, M. E. Jakobs, D. de Jong, P. E. Slagboom, F. J. Staal, M. J. Reinders, H. Holstege

This study examines clonal hematopoiesis and T-cell immunity in a supercentenarian, finding dynamic clonal expansion and preserved T-cell function despite extreme age.

bioRxiv · Jun 4, 2020Immunology