E. B. van den Akker

This study uses single-cell data to deconvolute bulk RNA-seq samples of AML, showing that differentiation stages can be reconstructed and used to predict drug responses like Venetoclax resistance.

The paper uses single-cell techniques to study human T cell development, identifying thymus-seeding progenitors and multi-lineage potential in the human thymus.

This study tracks longitudinal B-cell responses to Tdap vaccination using single-cell transcriptomics and BCR repertoires, identifying clonal expansion, class switching, and antigen-specific BCRs.

This study examines clonal hematopoiesis and T-cell immunity in a supercentenarian, finding dynamic clonal expansion and preserved T-cell function despite extreme age.

The paper presents a new population-matched immunoglobulin (pmIG) database containing accurate germline alleles from 26 human populations, revealing evolutionary patterns and diversity in IG loci.