Author

M. J. Reinders

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

E. B. van den Akker· 2 shared A. M. Otte· 1 shared C. J. Halkes· 1 shared D. de Jong· 1 shared E. O. Karakaslar· 1 shared E. Sanchez-Lopez· 1 shared F. Baas· 1 shared F. J. Staal· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

E. B. van den Akker

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2 papers

Recent·Most cited

Single cell guided deconvolution of bulk transcriptomics recapitulates differentiation stages of acute myeloid leukemia and predicts drug response

E. O. Karakaslar, J. F. Severens, E. Sanchez-Lopez, P. A. van Veelen, M. Zlei, J. J. van Dongen, A. M. Otte, C. J. Halkes, P. van Balen, H. Veelken, M. J. Reinders, M. Griffioen, E. B. van den Akker

This study uses single-cell data to deconvolute bulk RNA-seq samples of AML, showing that differentiation stages can be reconstructed and used to predict drug responses like Venetoclax resistance.

bioRxiv · Dec 9, 2022 · PreprintCancer Biology

DYNAMIC CLONAL HEMATOPOIESIS AND FUNCTIONAL T-CELL IMMUNITY IN A SUPER-CENTENARIAN

E. B. van den Akker, S. Makrodimitris, M. Hulsman, M. H. Brugman, T. Nikolic, T. Bradley, Q. Waisfisz, F. Baas, M. E. Jakobs, D. de Jong, P. E. Slagboom, F. J. Staal, M. J. Reinders, H. Holstege

This study examines clonal hematopoiesis and T-cell immunity in a supercentenarian, finding dynamic clonal expansion and preserved T-cell function despite extreme age.

bioRxiv · Jun 4, 2020Immunology