Author

O. M. Andersen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. Padzik· 2 shared C. B. Vaegter· 2 shared I. Paatero· 2 shared J. Ivaska· 2 shared A. M. G. Jensen· 1 shared A. M. P. Gjessing· 1 shared A. Manavalan· 1 shared A. Moller· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

A. Padzik

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Relying on the relationship with known disease-causing variants in homologous proteins to predict pathogenicity of SORL1 variants in Alzheimer's disease

O. M. Andersen, G. Monti, A. M. G. Jensen, M. de Waal, M. Hulsman, J. G. Olsen, H. Holstege

The paper predicts pathogenic SORL1 variants in Alzheimer's disease by analyzing homologous proteins with known disease-causing variants.

bioRxiv · Feb 27, 2023 · PreprintBiochemistry

Soluble SorCS1 binds the insulin receptor to enhance insulin sensitivity.

M. Kjolby, P. Breining, K. M. Pedersen, N. Wellner, K. M. J. Sorensen, A. M. P. Gjessing, D. Januliene, D. M. Vittrup, A. Manavalan, M. Rotman, G. Thotakura, G. Hermey, P. Madsen, C. B. Vaegter, S. Thirup, , A. Nykjaer

This study identifies sol-SorCS1 as a soluble form of SorCS1 that enhances insulin sensitivity by binding the insulin receptor, improving glucose uptake and signaling in myocytes.

bioRxiv · Nov 10, 2020 · PreprintPhysiology

Endosomal trafficking is required for glycosylation and normal maturation of the Alzheimer's-associated protein sorLA

S. K. Christensen, Y. Narimatsu, S. Simoes, C. K. Goth, C. B. Vaegter, S. A. Small, H. Clausen, O. M. Andersen

This study shows that endosomal trafficking is essential for sorLA maturation and shedding, with immature sorLA acquiring complex N-glycans upon retrograde transport.

bioRxiv · Jul 12, 2020 · PreprintCell Biology

A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance

H. Al-Akhrass, J. R. W. Conway, A. S. A. Poulsen, I. Paatero, J. Kaivola, A. Padzik, O. M. Andersen, J. Ivaska

This study identifies a feed-forward loop involving SorLA and HER3 that enhances heregulin response and neratinib resistance in breast cancer.

bioRxiv · Jun 10, 2020Cancer Biology

SORLA-driven endosomal trafficking regulates the oncogenic fitness of HER2

M. Pietila, P. Sahgal, E. Peuhu, N. Jantti, I. Paatero, O. M. Andersen, A. Padzik, M. Blomqvist, I. Saarinen, P. Bostrom, P. Taimen, J. Ivaska

This study shows SORLA regulates HER2 trafficking, affecting its oncogenic activity and response to therapy.

bioRxiv · Apr 11, 2018Cell Biology