H. I. Chen

The genetic basis of novel trait gain in walking fish

This study identifies key transcription factors for leg formation in sea robins and shows the role of tbx3a in chemosensory leg evolution.

Whole-genome comparisons identify repeated regulatory changes underlying convergent appendage evolution in diverse fish lineages

The paper identifies genomic deletions associated with convergent fin reduction in multiple fish lineages by comparing whole-genome sequences of 36 wild fish species.

Dopaminergic axon tracts within a hyaluronic acid hydrogel encasement for implantation to restore the nigrostriatal pathway

This paper develops a hyaluronic acid hydrogel-based tissue-engineered nigrostriatal pathway to restore dopamine function in Parkinson's disease by improving axon growth and reducing inflammation.

MXtrodes: MXene-infused bioelectronic interfaces for multiscale electrophysiology and stimulation

This paper introduces MXtrodes, a new class of bioelectronic interfaces using MXene for high-resolution, large-scale electrophysiology and stimulation, validated in human and animal applications.

Predicting future from past: The genomic basis of recurrent and rapid stickleback evolution

The paper identifies recurrent genomic loci involved in stickleback adaptation to freshwater habitats and shows they predict evolutionary changes in Darwin's finches.

Development of Optically-Controlled "Living Electrodes" with Long-Projecting Axon Tracts for a Synaptic Brain-Machine Interface

This paper develops and validates axon-based 'living electrodes' for a synaptic brain-machine interface, demonstrating their fabrication, function, and in vivo integration in rats.

Three-dimensional human axon tracts derived from cerebral organoids

This paper describes the generation of three-dimensional human axon tracts from cerebral organoids, which can be transplanted and mimic brain connectivity features.

A novel unbiased test for molecular convergent evolution and discoveries in echolocating, aquatic and high-altitude mammals

The paper introduces a novel test to identify molecular convergent evolution in coding genes across phenotypically convergent lineages, revealing 75 novel convergences in echolocating, aquatic, and high-altitude mammals.