Author

J. D. Sears

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

C. L. Mayberry· 2 shared C.-H. CHANG· 2 shared J. J. Wilson· 2 shared J. Wei· 2 shared A. C. Grammer· 1 shared A. Ghoshal· 1 shared A. L. Herbert· 1 shared A. L. Mordant· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersImmunology

C. L. Mayberry

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

IL-3-driven T cell-basophil crosstalk enhances anti-tumor immunity

J. Wei, C. L. Mayberry, X. Lv, F. Hu, J. D. Sears, T. Khan, N. A. Logan, J. J. Wilson, D. Chaussabel, C.-H. CHANG

This study shows that IL-3 enhances anti-tumor immunity by promoting CTL-basophil interactions, improving CTL activity and tumor suppression.

Cancer Immunology Research · May 10, 2024Peer-reviewedImmunology

Discovery of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach

E. M. Merten, J. D. Sears, T. M. Leisner, P. B. Hardy, A. Ghoshal, M. A. Hossain, K. H. Asressu, P. J. Brown, M. A. Stashko, L. E. Herring, A. L. Mordant, T. S. Webb, C. A. Mills, N. K. Barker, J. J. Arnold, , K. H. Pearce

This paper identifies and characterizes RA-0002034, a covalent inhibitor of CHIKV nsP2 protease, showing potent inhibition and selectivity against alphaviruses.

bioRxiv · Mar 22, 2024 · PreprintBiochemistry

The genetic basis of novel trait gain in walking fish

A. L. Herbert, C. A. Allard, M. J. McCoy, J. I. Wucherpfennig, S. P. Krueger, H. I. Chen, A. N. Gourlay, K. D. Jackson, L. A. Abbo, S. H. Bennett, J. D. Sears, A. L. Rhyne, N. W. Bellono, D. M. Kingsley

This study identifies key transcription factors for leg formation in sea robins and shows the role of tbx3a in chemosensory leg evolution.

bioRxiv · Oct 14, 2023Evolutionary Biology

Augmented glucose dependency of autoreactive B cells provides a treatment target forlupus

J. J. Wilson, J. Wei, A. R. Daamen, J. D. Sears, E. Bechtel, C. L. Mayberry, G. A. Stafford, L. Bechtold, A. C. Grammer, P. E. Lipsky, D. C. Roopenian, C.-H. Chang

This study identifies glycolysis-dependent autoreactive B cells as key mediators of lupus and shows that targeting them with 2DG or BCMA-specific CAR T-cells improves disease outcomes.

bioRxiv · Feb 1, 2022Immunology