A novel RyR1 inhibitor prevents and rescues sudden death in a mouse model of malignant hyperthermia and heat stroke
T. Yamazawa, T. Kobayashi, N. Kurebayashi, M. Konishi, S. Noguchi, T. Inoue, Y. U. Inoue, I. Nishino, S. Mori, H. Iinuma, N. Manaka, H. Kagechika, A. Uryas, J. Adams, J. R. Lopez, , T. Murayama
This study introduces a novel RyR1 inhibitor that prevents and rescues MH and heat stroke in mouse models, offering improved solubility and clearance compared to dantrolene.
bioRxiv · Jul 2, 2020 · PreprintPharmacology & Toxicology