Author

T. Yamazawa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

T. Murayama· 2 shared A. Uryas· 1 shared B. Lin· 1 shared C. Diggle· 1 shared H. Iinuma· 1 shared H. Kagechika· 1 shared H. Oyamada· 1 shared I. Nishino· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiophysics

T. Murayama

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Author profile →

2 papers

Recent·Most cited

Heat hypersensitivity of ryanodine receptor type 1 mutants implicated in malignant hyperthermia

K. Oyama, V. Zeeb, T. Yamazawa, T. Murayama, H. Oyamada, Y. Harada, N. Fukuda, S. Ishiwata, M. Suzuki

The paper shows that heat hypersensitive RyR1 mutants cause heat-induced Ca2+ release, contributing to malignant hyperthermia through a positive feedback loop.

bioRxiv · Oct 29, 2020 · PreprintBiophysics

A novel RyR1 inhibitor prevents and rescues sudden death in a mouse model of malignant hyperthermia and heat stroke

T. Yamazawa, T. Kobayashi, N. Kurebayashi, M. Konishi, S. Noguchi, T. Inoue, Y. U. Inoue, I. Nishino, S. Mori, H. Iinuma, N. Manaka, H. Kagechika, A. Uryas, J. Adams, J. R. Lopez, , T. Murayama

This study introduces a novel RyR1 inhibitor that prevents and rescues MH and heat stroke in mouse models, offering improved solubility and clearance compared to dantrolene.

bioRxiv · Jul 2, 2020 · PreprintPharmacology & Toxicology