Lack of antiviral activity of probenecid in Vero E6 cells and Syrian golden hamsters: a need for better understanding of inter-lab differences in preclinical assays.
H. J. Box, S. H. Pennington, E. Kijack, L. Tatham, C. H. Caygill, R. C. Lopeman, L. N. Jeffreys, J. Herriott, J. Sharp, M. Neary, A. Valentijn, H. Pertinez, P. Curley, U. Arshad, R. K. Rajoli, , A. Owen
This paper investigates probenecid's antiviral activity against SARS-CoV-2 in Vero E6 cells and Syrian golden hamsters, finding no significant inhibition of viral replication or cytopathic effects.
bioRxiv · Mar 3, 2022 · PreprintPharmacology & Toxicology