Author

A. Valentijn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 5 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:drug response / drug discovery· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:metabolomics· 1

Frequent Co-Authors

A. Owen· 6 shared H. Pertinez· 6 shared J. Sharp· 6 shared L. Tatham· 6 shared M. Neary· 6 shared P. Curley· 6 shared U. Arshad· 6 shared H. Box· 5 shared

Activity by Year

2021-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersPharmacology & Toxicology

A. Owen

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Lack of antiviral activity of probenecid in Vero E6 cells and Syrian golden hamsters: a need for better understanding of inter-lab differences in preclinical assays.

H. J. Box, S. H. Pennington, E. Kijack, L. Tatham, C. H. Caygill, R. C. Lopeman, L. N. Jeffreys, J. Herriott, J. Sharp, M. Neary, A. Valentijn, H. Pertinez, P. Curley, U. Arshad, R. K. Rajoli, , A. Owen

This paper investigates probenecid's antiviral activity against SARS-CoV-2 in Vero E6 cells and Syrian golden hamsters, finding no significant inhibition of viral replication or cytopathic effects.

bioRxiv · Mar 3, 2022 · PreprintPharmacology & Toxicology

Ronapreve (REGN-CoV; casirivimab and imdevimab) reduces the viral burden and alters the pulmonary response to the SARS-CoV 2 Delta variant (B.1.617.2) in K18-hACE2 mice using an experimental design reflective of a treatment use case

L. Tatham, A. Kipar, J. Sharp, E. Kijak, J. Herriott, M. Neary, H. Box, E. Gallardo Toledo, A. Valentijn, H. Cox, H. Pertinez, P. Curley, U. Arshad, R. K. Rajoli, S. Rannard, , A. Owen

This study evaluates Ronapreve's efficacy against SARS-CoV-2 Delta and Omicron variants in mice, showing reduced viral burden and altered pulmonary response for Delta but not Omicron.

bioRxiv · Jan 23, 2022Microbiology

Evaluation of intranasal nafamostat or camostat for SARS-CoV-2 chemoprophylaxis in Syrian golden hamsters

M. Neary, H. Box, J. Sharp, L. Tatham, P. Curley, J. Herriott, E. Kijak, U. Arshad, J. J. Hobson, R. K. Rajoli, H. Pertinez, A. Valentijn, K. Dhaliwal, F. McCaughan, S. P. Rannard, , A. Owen

This study evaluates intranasal nafamostat and camostat for preventing SARS-CoV-2 infection in Syrian golden hamsters, finding nafamostat effective in keeping viral RNA undetectable for 7 days.

bioRxiv · Jul 8, 2021 · PreprintPharmacology & Toxicology

Quantitation of tizoxanide in multiple matrices to support cell culture, animal and human research.

M. Neary, U. Arshad, L. Tatham, H. Pertinez, H. Box, R. K. Rajoli, A. Valentijn, J. Sharp, S. P. Rannard, G. A. Biagini, P. Curley, A. Owen

The paper describes an LC-MS/MS assay validated for quantifying tizoxanide in human plasma, mouse plasma, and DMEM with FBS, showing high accuracy and precision.

bioRxiv · May 27, 2021Pharmacology & Toxicology

Development of a highly sensitive bioanalytical assay for the quantification of favipiravir.

P. Curley, M. Neary, U. Arshad, L. Tatham, H. Pertinez, H. Box, R. K. R. Rajoli, A. Valentijn, J. Sharp, S. Rannard, A. Owen

This paper develops a sensitive LC-MS/MS assay for quantifying favipiravir, showing high accuracy and precision across a wide concentration range.

bioRxiv · Feb 3, 2021 · PreprintPharmacology & Toxicology

Optimisation and validation of a sensitive bioanalytical method for niclosamide.

U. Arshad, H. Pertinez, H. Box, L. Tatham, R. Rajoli, M. Neary, J. Sharp, A. Valentijn, J. Hobson, C. Unsworth, A. Dwyer, A. Savage, T. McDonald, S. Rannard, P. Curley, A. Owen

The paper develops and validates a sensitive LC-MS/MS assay for niclosamide to study its pharmacokinetics and potential use in preclinical and clinical evaluations.

bioRxiv · Jan 13, 2021 · PreprintPharmacology & Toxicology