Experimental adaptation of dengue virus 1 to Aedes albopictus mosquitoes by in vivo selection
R. Bellone, S. Lequime, H. Jupille, G. Goertz, F. Aubry, L. Mousson, G. Piorkowski, P.-S. Yen, G. Gabiane, M. Vazeille, G. Pijlman, A. Sakuntabhai, X. de Lamballerie, L. Lambrechts, A.-B. Failloux
This study adapts DENV-1 to Ae. albopictus mosquitoes through in vivo selection, identifying adaptive mutations that enhance infectivity but show limited individual transmission efficiency.
bioRxiv · Jul 16, 2020Microbiology