Author

G. Piorkowski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Organism:virus· 2 Assay:whole-genome sequencing· 2 Approach:biophysical modeling· 1 Organism:Drosophila· 1

Frequent Co-Authors

X. de Lamballerie· 5 shared F. Touret· 4 shared A. Nougairede· 3 shared G. Moureau· 3 shared J.-S. Driouich· 3 shared R. Klitting· 3 shared B. Coutard· 2 shared H. S. Bouzidi· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersMicrobiology

X. de Lamballerie

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Genomic surveillance reveals that the dengue 2 virus lineage responsible for the 2023-2024 epidemic in the French Caribbean Islands is resistant to Mosnodenvir

H. S. Bouzidi, S. Sen, G. Piorkowski, L. Pezzi, N. Ayhan, A. Fontaine, T. Canivez, M. Geulen, R. Amaral, G. Grard, G. A. Durand, X. de Lamballerie, F. Touret, R. Klitting

The paper identifies a mutation in dengue virus genomes from the 2023-2024 French Caribbean epidemic that confers resistance to the anti-dengue compound mosnodenvir.

bioRxiv · Apr 10, 2024 · PreprintMicrobiology

In vivo rescue of arboviruses directly from subgenomic DNA fragments

M. Cochin, J.-S. Driouich, G. Moureau, G. Piorkowski, X. N. de Lamballerie, A. Nougairede

The paper demonstrates an in vivo method to generate arboviruses from subgenomic DNA fragments, achieving 100% infection rate in mice with optimized electroporation parameters.

bioRxiv · Jan 17, 2024 · PreprintMicrobiology

Generation and evaluation of protease inhibitor-resistant SARS-CoV-2 strains

H. S. Bouzidi, J.-S. Driouich, R. Klitting, O. Bernadin, G. Piorkowski, R. Amaral, L. Fraisse, C. E. Mowbray, I. Scandale, F. Escudie, E. Chatelain, X. de Lamballerie, A. Nougairede, F. Touret

The paper generates and evaluates SARS-CoV-2 mutants resistant to protease inhibitors nirmatrelvir and ensitrelvir, showing in vitro and in vivo resistance and linking M49L mutation prevalence to Xocova(R) use.

bioRxiv · Nov 22, 2023Microbiology

Experimental adaptation of dengue virus 1 to Aedes albopictus mosquitoes by in vivo selection

R. Bellone, S. Lequime, H. Jupille, G. Goertz, F. Aubry, L. Mousson, G. Piorkowski, P.-S. Yen, G. Gabiane, M. Vazeille, G. Pijlman, A. Sakuntabhai, X. de Lamballerie, L. Lambrechts, A.-B. Failloux

This study adapts DENV-1 to Ae. albopictus mosquitoes through in vivo selection, identifying adaptive mutations that enhance infectivity but show limited individual transmission efficiency.

bioRxiv · Jul 16, 2020Microbiology

Favipiravir antiviral efficacy against SARS-CoV-2 in a hamster model

J.-S. Driouich, M. Cochin, G. Lingas, G. Moureau, F. Touret, P.-R. Petit, G. Piorkowski, K. Barthelemy, B. Coutard, J. Guedj, X. de Lamballerie, C. Solas, A. Nougairede

This study evaluates favipiravir's antiviral efficacy against SARS-CoV-2 in a Syrian hamster model, showing dose-dependent reduction of viral titers and disease symptoms.

bioRxiv · Jul 7, 2020Microbiology

Favipiravir strikes the SARS-CoV-2 at its Achilles heel, the RNA polymerase

A. Shannon, B. Selisko, T.-T.-N. Le, J. Huchting, F. Touret, G. Piorkowski, V. Fattorini, F. Ferron, E. Decroly, C. Meier, B. Coutard, O. Peersen, B. Canard

This study shows Favipiravir inhibits SARS-CoV-2 by targeting its RNA polymerase through chain termination, slowed synthesis, and mutagenesis.

bioRxiv · May 15, 2020 · PreprintBiochemistry

Exploratory re-encoding of Yellow Fever Virus genome: new insights for the design of live-attenuated viruses

R. Klitting, T. Riziki, G. Moureau, G. Piorkowski, E. A. Gould, X. de Lamballerie

This study re-encodes the Yellow Fever Virus genome with synonymous mutations to create attenuated strains, finding that certain mutations reduce virulence without significantly affecting replication fitness.

bioRxiv · May 30, 2018Microbiology