L. Lambrechts

Atypical landscape of transposable elements in the large genome of Aedes aegypti

This study compares transposable element organization in the large Aedes aegypti genome to smaller Diptera genomes, finding higher TE transposition and lower elimination rates in Ae. aegypti.

Extensive variation and strain-specificity in dengue virus susceptibility among African Aedes aegypti populations

This study investigates dengue virus susceptibility in African Aedes aegypti populations and finds significant variation and strain-specific interactions.

Differential intra-host infection kinetics in Aedes aegypti underlie superior transmissibility of African relative to Asian Zika virus

This study compares intra-host infection kinetics of African and Asian Zika virus in Aedes aegypti, finding the African lineage replicates faster and spreads more efficiently.

Zika viruses encode multiple upstream open reading frames in the 5' viral region with a role in neurotropism

This study identifies multiple upstream open reading frames (uORFs) in Zika virus (ZIKV) that influence neurotropism but not mosquito transmission.

Molecular signature of domestication in the arboviral vector Aedes aegypti

The paper identifies a molecular signature of domestication in Aedes aegypti by analyzing genome-wide SNPs and finding genetic differentiation between domestic and generalist forms.

Multifaceted contributions of Dicer2 to arbovirus transmission by Aedes aegypti

This study investigates the role of Dicer2 in arbovirus transmission by Aedes aegypti, finding it affects early viral replication and mortality but not overall vector competence.

Mosquito-bacteria interactions during larval development trigger metabolic changes with carry-over effects on adult fitness

This study shows that larval exposure to specific bacteria in mosquitoes alters lipid metabolism, affecting adult survival and fitness.

In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of plasma viremia

This study uses STIP-Seq to analyze HIV-1 reservoirs and identifies proviral features and cellular sources contributing to plasma viremia in ART-suppressed individuals.

Extensive characterization of HIV-1 reservoirs reveals links to plasma viremia before and during analytical treatment interruption

This study characterizes HIV-1 reservoirs in four individuals during treatment interruption, identifying proviruses linked to plasma viremia and showing their role in viral rebound.

High transmissibility and fetal pathogenicity of recent Zika virus strains from the African lineage

This study compares transmissibility and pathogenicity of recent African and Asian Zika virus strains, finding African strains more transmissible, lethal, and capable of causing fetal death.

Experimental adaptation of dengue virus 1 to Aedes albopictus mosquitoes by in vivo selection

This study adapts DENV-1 to Ae. albopictus mosquitoes through in vivo selection, identifying adaptive mutations that enhance infectivity but show limited individual transmission efficiency.

Non-retroviral endogenous viral element limits cognate virus replication in Aedes aegypti ovaries

The paper shows that a non-retroviral EVE in Aedes aegypti limits replication of its cognate virus, CFAV, through piRNA-mediated antiviral activity in ovaries.

BiteOscope: an open platform to study mosquito blood-feeding behavior

BiteOscope quantifies mosquito blood-feeding behavior using a host mimic and machine learning, revealing DEET repels Anopheles coluzzii.

Tudor-SN promotes early replication of dengue virus in the Aedes aegypti midgut

This study identifies Tudor-SN as a proviral factor that promotes early dengue virus replication in Aedes aegypti midgut cells.

Uncovering The Repertoire Of Endogenous Flaviviral Elements In Aedes Mosquito Genomes

This study identifies and characterizes endogenous flaviviral elements in Aedes mosquito genomes, revealing structural diversity and RNA-based functions.

Extensive genetic differentiation between homomorphic sex chromosomes in the mosquito vector, Aedes aegypti

The paper shows that sex chromosomes in Aedes aegypti are genetically differentiated over a large region, not just a small sex-determining region, and demonstrates how this can be used for accurate sex assignment and population genomic studies.