H. K. Alexander

Estimating mutation rates under heterogeneous stress responses

This paper develops a population dynamic model to estimate mutation rate increases under heterogeneous stress responses in bacteria, showing it can accurately infer mutation rate changes when stress responses also reduce division rates.

Stochastic bacterial population dynamics prevent the emergence of antibiotic resistance from single cells

This paper shows that low antibiotic concentrations can prevent resistance emergence from single cells due to stochastic effects, challenging deterministic models.

Effective polyploidy causes phenotypic delay and influences bacterial evolvability

This study shows antibiotic resistance mutations in E. coli have a 3-4 generation phenotypic delay due to effective polyploidy, impacting mutation rate estimation and evolutionary adaptation.