The human leukemic oncogene MLL-AF4 promotes hyperplastic growth of hematopoietic tissues in Drosophila larvae
J. A. Johannessen, M. Formica, N. R. Brathen, A. Al Outa, M. Aarsund, M. Therrien, J. M. Enserink, H. Knaevelsrud
This study uses a Drosophila model to show that MLL-AF4 promotes hematopoietic hyperplasia and that DOT1L inhibition can reverse the leukemia-like phenotype.
bioRxiv · Nov 8, 2022 · PreprintCancer Biology