Author

H. Koohy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Research Focus:cell type annotation· 4 Organism:human· 4 Assay:proteomics· 4 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Simmons· 4 shared C. H.-J. Lee· 3 shared P. Buckley· 3 shared A. Antanaviciute· 2 shared G. Ogg· 2 shared J. Woo· 2 shared A. Lubbock· 1 shared C. Hyun-Jung Lee· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersImmunology

A. Simmons

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Author profile →

5 papers

Recent·Most cited

A comparison of clustering models for inference of T cell receptor antigen specificity

H. Koohy, D. Hudson, A. Lubbock, M. Basham

This study compares clustering models for predicting T cell receptor (TCR) antigen specificity, finding variability in performance and scalability but high similarity in clusters for TCRs recognizing the same epitope.

bioRxiv · Aug 4, 2023Immunology

A systems approach evaluating the impact of SARS-CoV-2 variant of concern mutations on CD8+ T cell responses

P. R. Buckley, C. H.-J. Lee, A. Antanaviciute, A. Simmons, H. Koohy

This study evaluates how SARS-CoV-2 variant mutations affect CD8+ T cell responses using immunogenicity scores and in-silico mutagenesis.

bioRxiv · Oct 21, 2022 · PreprintImmunology

HLA-dependent variation in SARS-CoV-2 CD8+ T cell cross-reactivity with human coronaviruses

P. Buckley, C. H.-j. Lee, M. P. Pinho, R. O. Babu, J. Woo, A. Antanaviciute, A. Simmons, G. Ogg, H. Koohy

This study identifies SARS-CoV-2 peptides with cross-reactivity to human coronaviruses and shows that TCR repertoires in COVID-19 patients are HLA-dependent.

bioRxiv · Jul 17, 2021Immunology

Evaluating performance of existing computational models in predicting CD8+ T cell pathogenic epitopes and cancer neoantigens

P. Buckley, R. Ma, C. H.-J. Lee, I. Woodhouse, J. Woo, V. O. Tsvetkov, D. S. Shcherbinin, M. Shugay, M. Rei, A. Simmons, H. Koohy

This study evaluates existing computational models for predicting CD8+ T cell epitopes and cancer neoantigens, finding poor performance for emerging viruses and cancer peptides.

bioRxiv · Dec 25, 2020Immunology

CD8+ T cell cross-reactivity against SARS-CoV-2 conferred by other coronavirus strains and influenza virus

H. Koohy, C. Hyun-Jung Lee, M. Pereira Pinho, P. Buckley, I. B. Woodhouse, G. Ogg, A. Simmons, G. Napolitani

The paper investigates T cell cross-reactivity against SARS-CoV-2 from other coronaviruses and influenza virus, identifies epitopes, and supports vaccine development.

bioRxiv · May 20, 2020Immunology