J. Woo

Dual-mode action of scalable, high-quality engineered stem cell-derived SIRPα-extracellular vesicles for treating acute liver failure

This paper develops SIRPα-expressing extracellular vesicles from engineered stem cells to treat acute liver failure by resolving necroptosis and promoting liver regeneration, showing reduced liver damage and improved survival in models.

An RXLR effector targets ER-Golgi interface to induce ER stress and necrotic cell death

This study identifies Pc12, an RXLR effector from P. capsici, which induces necrotic cell death by disrupting ER-Golgi trafficking through interaction with Rab13-2.

CRISPR screens and lectin microarrays identify novel high mannose N-glycan regulators

The paper uses CRISPR screens and lectin microarrays to identify TM9SF3 and the CCC complex as novel regulators of high mannose N-glycan synthesis.

Tumor-wide RNA splicing aberrations generate immunogenic public neoantigens

The paper identifies tumor-wide splicing aberrations that generate public neoantigens, enabling T-cell-based immunotherapies targeting intratumoral heterogeneity.

Non-coding sequence variation reveals fragility within interleukin 2 feedback circuitry and shapes autoimmune disease risk

The paper shows how non-coding variants affecting IL2RA enhancers alter T cell feedback circuits, leading to opposing autoimmune outcomes in mice.

Remote neuronal activity drives glioma infiltration via Sema4f

This study identifies callosal projection neurons as drivers of glioma infiltration through Sema4F-mediated activity-dependent signaling in mouse and human tumors.

Isolation may select for earlier and higher peak viral load but shorter duration in SARS-CoV-2 evolution

This study shows isolation measures during the pandemic selected for SARS-CoV-2 variants with earlier and higher peak viral loads but shorter infection duration.

Diversity, composition, altitude, and seasonality of high-altitude windborne migrating mosquitoes in the Sahel: Implications for disease transmission

The paper identifies high-altitude windborne mosquito migration in the Sahel, showing its role in disease transmission and highlighting key pathogens transported by these mosquitoes.

Helminth egg derivatives as pro-regenerative immunotherapies

This study develops a regenerative immunotherapy using helminth-derived soluble egg antigen to promote tissue repair in multiple injury models.

Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL

The paper identifies 14q32 cluster miRNAs as key regulators of transcriptional differences between IGHV-mutated and unmutated CLL, with miR-409-3p and miR-411-3p repressing GAB1.

Potent universal-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing monoclonal antibody

This study identifies a potent universal coronavirus neutralizing monoclonal antibody, 1249A8, effective against multiple variants and demonstrating therapeutic activity through intranasal administration.

Different efficacies of neutralizing antibodies and antiviral drugs on SARS-CoV-2 Omicron subvariants, BA.1 and BA.2

The paper compares the efficacy of neutralizing antibodies and antiviral drugs against SARS-CoV-2 Omicron subvariants BA.1 and BA.2, finding differential responses to specific treatments.

The African mosquito-borne diseasosome: Geographical patterns and range expansion

The paper maps the geographical patterns of mosquito-borne diseases in Africa, identifying key pathogens and vectors, and highlights risks for disease emergence.

HLA-dependent variation in SARS-CoV-2 CD8+ T cell cross-reactivity with human coronaviruses

This study identifies SARS-CoV-2 peptides with cross-reactivity to human coronaviruses and shows that TCR repertoires in COVID-19 patients are HLA-dependent.

Evaluating performance of existing computational models in predicting CD8+ T cell pathogenic epitopes and cancer neoantigens

This study evaluates existing computational models for predicting CD8+ T cell epitopes and cancer neoantigens, finding poor performance for emerging viruses and cancer peptides.

Thermosensitivity of the voltage-dependent activation of calcium homeostasis modulator 1 (calhm1) ion channel

This study shows that calhm1 ion channel activation is thermosensitive, with increased amplitude and faster activation at higher temperatures, independent of extracellular calcium concentration.

Therapeutic activity of an inhaled potent SARS-CoV-2 neutralizing human monoclonal antibody in hamsters

This study evaluates an inhaled monoclonal antibody against SARS-CoV-2 in hamsters, showing reduced viral burden and lung pathology with low-dose inhalation.

Genomic programming of antigen cross-presentation in IRF4-expressing human Langerhans cells

The paper identifies IRF4 as a key transcription factor driving antigen cross-presentation in human Langerhans cells, distinguishing them from conventional dendritic cells.