A. Antanaviciute

Human enteric glia diversity in health and disease: new avenues for the treatment of Hirschsprung disease

This study identifies two enteric glia classes in health and disease, showing Schwann-like glia persist in HSCR and can be targeted to stimulate neurogenesis in a zebrafish model.

A systems approach evaluating the impact of SARS-CoV-2 variant of concern mutations on CD8+ T cell responses

This study evaluates how SARS-CoV-2 variant mutations affect CD8+ T cell responses using immunogenicity scores and in-silico mutagenesis.

HLA-dependent variation in SARS-CoV-2 CD8+ T cell cross-reactivity with human coronaviruses

This study identifies SARS-CoV-2 peptides with cross-reactivity to human coronaviruses and shows that TCR repertoires in COVID-19 patients are HLA-dependent.

BMP pathway antagonism by Grem1 regulates epithelial cell fate in intestinal regeneration

This study shows that Grem1 antagonizes BMP signaling to regulate epithelial cell fate during intestinal regeneration.

Targeting BDCA2 suppresses Plasmacytoid dendritic cell dependent interferon response and tissue fibrosis

This study shows that targeting BDCA2 reduces pDC-driven interferon responses and fibrosis in preclinical models of skin inflammation.

Type-1 IFN primed monocytes in pathogenesis of idiopathic pulmonary fibrosis

The paper identifies type-1 IFN-primed monocytes as key drivers of fibrosis in IPF, showing their increased levels, altered phenotype, and potential as therapeutic targets.

Plasmacytoid dendritic cells are functionally exhausted while non-haematopoietic sources of type I interferon dominate human autoimmunity

The paper shows that plasmacytoid dendritic cells are functionally exhausted in autoimmunity, and non-haematopoietic sources like keratinocytes drive type I interferon production.