A. Simmons

Human enteric glia diversity in health and disease: new avenues for the treatment of Hirschsprung disease

This study identifies two enteric glia classes in health and disease, showing Schwann-like glia persist in HSCR and can be targeted to stimulate neurogenesis in a zebrafish model.

Mutational order and epistasis determine the consequences of FBXW7 mutations during colorectal cancer evolution

This study shows that the order of FBXW7 and APC mutations affects colorectal cancer initiation, with FBXW7 mutations before APC preventing cancer-like features.

A systems approach evaluating the impact of SARS-CoV-2 variant of concern mutations on CD8+ T cell responses

This study evaluates how SARS-CoV-2 variant mutations affect CD8+ T cell responses using immunogenicity scores and in-silico mutagenesis.

HLA-dependent variation in SARS-CoV-2 CD8+ T cell cross-reactivity with human coronaviruses

This study identifies SARS-CoV-2 peptides with cross-reactivity to human coronaviruses and shows that TCR repertoires in COVID-19 patients are HLA-dependent.

BMP pathway antagonism by Grem1 regulates epithelial cell fate in intestinal regeneration

This study shows that Grem1 antagonizes BMP signaling to regulate epithelial cell fate during intestinal regeneration.

Evaluating performance of existing computational models in predicting CD8+ T cell pathogenic epitopes and cancer neoantigens

This study evaluates existing computational models for predicting CD8+ T cell epitopes and cancer neoantigens, finding poor performance for emerging viruses and cancer peptides.

CD8+ T cell cross-reactivity against SARS-CoV-2 conferred by other coronavirus strains and influenza virus

The paper investigates T cell cross-reactivity against SARS-CoV-2 from other coronaviruses and influenza virus, identifies epitopes, and supports vaccine development.

African Salmonella Typhimurium sequence type 313 lineage 2 evades MAIT cell recognition by overexpressing RibB

The paper shows African S. Typhimurium lineage 2 strains evade MAIT cell recognition by overexpressing ribB, which may contribute to their pathogenicity.

Ataxin-3 links NOD2 and TLR2 mediated innate immune sensing and metabolism in myeloid cells

This study identifies ataxin-3 as a mediator of NOD2 and TLR2 signaling in myeloid cells, linking innate immune sensing to metabolic processes and mitochondrial function.

NOD2 and TLR2 Signal via TBK1 and PI31 to Direct Cross-presentation and CD8 T Cell Responses

This study identifies TBK1 and PI31 as key mediators of NOD2 and TLR2 signaling in dendritic cells, enhancing cross-presentation and CD8+ T cell responses against bacterial pathogens.

A quantitative chemotherapy genetic interaction map reveals new factors associated with PARP inhibitor resistance

This paper creates a quantitative chemical-genetic interaction map in human cells to identify factors affecting chemotherapy response and resistance.