H. L. T. Mobley

Altered motility in response to iron-limitation is regulated by lpdA in uropathogenic E. coli CFT073

This study shows that lpdA regulates iron-mediated motility in UPEC, which impacts virulence under iron-limited conditions.

Conserved metabolic regulator ArcA responds to oxygen availability, iron limitation, and cell envelope perturbations during bacteremia

This study identifies ArcA as a conserved metabolic regulator in Gram-negative bacteria during bacteremia, showing its role in adapting to oxygen, iron, and membrane stress.

Klebsiella pneumoniae causes bacteremia using factors that mediate tissue-specific fitness and resistance to oxidative stress

This study identifies 58 K. pneumoniae genes critical for bloodstream fitness during bacteremia, revealing tissue-specific mechanisms and resistance to oxidative stress.

Phenotypic Assessment of Clinical Escherichia coli Isolates Predicts Uropathogenic Potential

This study uses phenotypic assays to predict uropathogenic potential of Escherichia coli isolates from UTI cases, showing that certain phenotypes correlate with infection severity.

Ferric Citrate Uptake is a Virulence Factor in Uropathogenic Escherichia coli

This study identifies the ferric citrate uptake system as a virulence factor in UPEC, showing its role in iron acquisition during UTI and its importance for bacterial fitness.

The Gene Expression Profile of Uropathogenic Escherichia coli in Women with Uncomplicated Urinary Tract Infections Is Recapitulated in the Mouse Model

This study compares gene expression of UPEC in human UTIs and a mouse model, finding strong correlation and validating the mouse model's utility for UTI research.

A systematic analysis of hypermucoviscosity and capsule reveals distinct and overlapping genes that impact Klebsiella pneumoniae fitness

This study identifies genes affecting capsule and hypermucoviscosity in Klebsiella pneumoniae, showing their integration with central metabolism for bacterial fitness.

Optimization of an Experimental Vaccine to Prevent Escherichia coli Urinary Tract Infection

This study optimizes an intranasal vaccine against UPEC UTI using dmLT adjuvant and Hma/IutA antigens, significantly reducing bladder colonization.

The Klebsiella pneumoniae citrate synthase gene, gltA, influences site specific fitness during infection

This study identifies the Kp citrate synthase gene gltA as critical for metabolic flexibility during infection, showing organ-specific fitness defects in lung and gut colonization.