Author

A. N. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

H. L. T. Mobley· 2 shared M. A. Bachman· 2 shared M. T. Anderson· 2 shared A. C. Frenk Oquendo· 1 shared A. M. Alousi· 1 shared A. Swennes· 1 shared B. A. Rohrman· 1 shared B. E. Bolivar· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersMicrobiology

H. L. T. Mobley

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Fitness Factor Genes Conserved within the Multi-species Core Genome of Gram-negative Enterobacterales Species Contribute to Bacteremia Pathogenesis

H. L. T. Mobley, M. T. Anderson, B. L. Moricz, G. S. Severin, C. L. Holmes, E. N. Ottosen, T. Eichler, S. Gupta, S. Paudel, R. Sinha, S. Mason, S. D. Himpsl, A. N. Brown, M. L. Gaca, C. M. Kiser, , M. A. Bachman

The paper identifies 18 conserved fitness genes in Enterobacterales species that contribute to bacteremia pathogenesis by testing mutants in a mouse model and finding attenuation in multiple organs.

PLOS Pathogens · Aug 23, 2024Peer-reviewedMicrobiology

Conserved metabolic regulator ArcA responds to oxygen availability, iron limitation, and cell envelope perturbations during bacteremia

A. N. Brown, M. T. Anderson, S. Smith, M. A. Bachman, H. L. T. Mobley

This study identifies ArcA as a conserved metabolic regulator in Gram-negative bacteria during bacteremia, showing its role in adapting to oxygen, iron, and membrane stress.

bioRxiv · Apr 18, 2023Microbiology

Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment

Z. Schwabkey, D. Wiesnoski, C.-C. Chang, W.-B. Tsai, D. Pham, S. S. Ahmed, T. Hayase, M. R. Ortega Turrubiates, R. K. El-Himri, C. A. Sanchez, E. Hayase, A. C. Frenk Oquendo, T. Miyama, T. M. Halsey, B. E. Heckel, , E. J. Shpall

The paper links diet-derived metabolites and mucus to fever after cytotoxic cancer treatment by showing how Akkermansia muciniphila affects colonic mucus and inflammation.

bioRxiv · Sep 18, 2021Microbiology

Non-canonical roles of caspase-4 and caspase-5 in heme driven- IL-1β release and cell death

B. E. Bolivar, A. N. Brown, B. A. Rohrman, C. I. Charendoff, V. Yazdani, J. D. Belcher, G. M. Vercellotti, J. M. Flanagan, L. Bouchier-Hayes

This paper identifies extracellular heme as a DAMP that activates caspase-1, caspase-4, and caspase-5, leading to IL-1β release and cell death in macrophages, with caspase-4 playing a primary role in cell death.

bioRxiv · Feb 28, 2020Immunology