Author

H. M. Williams

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 3 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:cryo-EM· 3 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:virus· 2 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

D. Vogel· 4 shared M. Rosenthal· 4 shared C. Busch· 3 shared M. Milewski· 3 shared S. Cusack· 3 shared S. R. Thorkelsson· 3 shared E. R. J. Quemin· 2 shared K. Grunewald· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersBiochemistry

D. Vogel

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structural snapshots of phenuivirus cap-snatching and transcription

H. M. Williams, S. R. Thorkelsson, D. Vogel, C. Busch, M. Milewski, S. Cusack, K. Grunewald, E. R. J. Quemin, M. Rosenthal

The paper presents cryo-EM structures of SFTSV L protein during cap-snatching and transcription, revealing conformational changes and RNA binding mechanisms.

bioRxiv · Nov 29, 2023Biochemistry

An RNA to rule them all: Critical steps in Lassa virus ribonucleoparticle assembly and recruitment

L. Saenger, H. M. Williams, D. Yu, D. Vogel, J. Kosinski, M. Rosenthal, C. Uetrecht

This study identifies RNA's role in disassembling NP trimers and forming RNA-bound assemblies, and shows Z protein interaction with NP is pH-dependent.

bioRxiv · Feb 9, 2023Biophysics

Structural insights into viral genome replication by the Severe fever with thrombocytopenia syndrome virus L protein

H. M. Williams, S. R. Thorkelsson, D. Vogel, M. Milewski, C. Busch, S. Cusack, K. Grunewald, E. Quemin, M. Rosenthal

This study presents cryo-EM structures of the SFTSV L protein during genome replication, revealing RNA binding and elongation mechanisms.

Nucleic Acids Research · Jan 18, 2023Peer-reviewedBiochemistry

Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity

T. Kouba, D. Vogel, S. R. Thorkelsson, E. R. J. Quemin, H. M. Williams, M. Milewski, C. Busch, S. Guenther, K. Gruenewald, M. Rosenthal, S. Cusack

This study presents cryo-EM structures of Lassa virus L protein in different states, revealing conformational changes linked to promoter binding and RNA synthesis, and supports antiviral drug development.

bioRxiv · Jun 24, 2021Biochemistry