S. Guenther

SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug discovery

The paper identifies ligands binding to the SARS-CoV-2 nsp10-16 complex using X-ray crystallography and reports their structures, providing insights for drug discovery.

Border-zone cardiomyocytes and macrophages contribute to remodeling of the extracellular matrix to promote cardiomyocyte invasion during zebrafish cardiac regeneration

This study identifies border-zone cardiomyocytes and macrophages as key contributors to ECM remodeling that facilitates cardiomyocyte invasion during zebrafish cardiac regeneration.

The aging-induced long non-coding RNA MIRIAL controls endothelial cell and mitochondrial function

This paper identifies MIRIAL as an aging-induced lncRNA that regulates endothelial quiescence and mitochondrial function through a novel triplex mechanism.

Temperatures above 37°C increase virulence of a convergent Klebsiella pneumoniae sequence type 307 strain

This study shows that temperatures above 37°C increase hypermucoviscosity and virulence in a convergent Klebsiella pneumoniae strain, potentially due to plasmid-encoded factors and temperature-dependent regulatory changes.

Multi-omics investigations uncover unique pathogenic markers in clinical Klebsiella pneumoniae that could be leveraged as novel antimicrobial targets

This study identifies unique pathogenic markers in Klebsiella pneumoniae through multi-omics analysis, suggesting potential novel antimicrobial targets.

Age-dependent RGS5 loss in pericytes induces cardiac dysfunction and fibrosis in the heart

This study shows that loss of RGS5 in pericytes with age leads to cardiac dysfunction and fibrosis by altering pericyte function and activating fibroblasts.

Antibiotic prophylaxis and hospitalization of horses subjected to median laparotomy: gut microbiota trajectories and abundance increase of Escherichia

This study examines the impact of peri-operative antibiotic prophylaxis on gut microbiota in horses undergoing median laparotomy, finding increased ESBL-producing bacteria and reduced diversity.

Engineering living immunotherapeutic agents for improved cancer treatment

This study investigates the immunostimulatory properties and therapeutic potential of magnetotactic bacteria (MTB) for immune-mediated cancer therapy.

LRBA balances antigen presentation and T-cell responses via autophagy through the binding to PIK3R4 and FYCO1

This study identifies LRBA's role in balancing antigen presentation and T-cell responses by interacting with PIK3R4 and FYCO1 to regulate autophagy.

Unravelling the impact of aging on the human endothelial lncRNA transcriptome

This study identifies age-related changes in lncRNA expression in human endothelial cells, highlighting PCAT14 as a key regulator of endothelial function and aging.

A novel role for cystathionine gamma lyase in the control of p53: impact on endothelial senescence and metabolic reprograming

This paper identifies CSE-p53 interaction as a regulator of endothelial cell senescence and metabolic reprogramming in aging, showing that restoring this interaction can prevent senescence and promote vascular repair.

Extracellular vesicles induce aggressive lung cancervia non-canonical integrin-EGFR-KRAS signaling

This study identifies a non-canonical ITGB2 signaling pathway that activates EGFR and RAS/MAPK/ERK in SCLC, leading to aggressive tumor behavior and resistance to EGFR inhibitors.

SARS-CoV-2 papain-like protease PLpro in complex with natural compounds reveal allosteric sites for antiviral drug design

This study identifies three natural compounds that inhibit SARS-CoV-2 PLpro by binding to the ISG15/Ub-S2 allosteric site, showing antiviral activity and potential for drug design.

Ageing impairs the neuro-vascular interface in the heart

This study shows aging reduces nerve density in the left ventricle and dysregulates neuro-regulatory genes, leading to reduced heart rate variability.

The regional distribution of resident immune cells shapes distinct immunological environments along the murine epididymis

The paper identifies region-specific immune cell subsets in the murine epididymis using scRNA-seq, revealing distinct immunological environments along the duct.

FGF10 triggers de novo alveologenesis in a BPD model: impact on the resident mesenchymal niche cells

This study shows that FGF10 administration rescues alveologenesis defects in a BPD mouse model by activating resident mesenchymal niche cells.

Reorganization of F-actin nanostructures is required for the late phases of SARS-CoV-2 replication in pulmonary cells.

This study shows that reorganization of F-actin nanostructures is critical for late stages of SARS-CoV-2 replication in pulmonary cells, with alpha-actinins playing a key role.

Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity

This study presents cryo-EM structures of Lassa virus L protein in different states, revealing conformational changes linked to promoter binding and RNA synthesis, and supports antiviral drug development.

Inhibition of SARS-CoV-2 main protease by allosteric drug-binding

The paper identifies 37 compounds binding to SARS-CoV-2 main protease through X-ray crystallography, with five non-peptidic compounds showing antiviral activity in cell-based assays.

SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes

This study shows SARS-CoV-2 infects human cardiomyocytes, causing cytotoxicity and apoptosis, and confirms this in cardiac tissue models.

Structural and functional characterization of the Severe fever with thrombocytopenia syndrome virus L protein

This study characterizes the structure and function of the SFTSV L protein using cryo-EM and X-ray crystallography to inform antiviral strategies.