Author

M. Rosenthal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Assay:cryo-EM· 3 Organism:virus· 3 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:drug response / drug discovery· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

D. Vogel· 5 shared C. Busch· 4 shared H. M. Williams· 4 shared S. Cusack· 4 shared S. R. Thorkelsson· 4 shared E. R. J. Quemin· 3 shared M. Milewski· 3 shared K. Gruenewald· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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5 shared papersBiochemistry

D. Vogel

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Structural snapshots of phenuivirus cap-snatching and transcription

H. M. Williams, S. R. Thorkelsson, D. Vogel, C. Busch, M. Milewski, S. Cusack, K. Grunewald, E. R. J. Quemin, M. Rosenthal

The paper presents cryo-EM structures of SFTSV L protein during cap-snatching and transcription, revealing conformational changes and RNA binding mechanisms.

bioRxiv · Nov 29, 2023Biochemistry

An RNA to rule them all: Critical steps in Lassa virus ribonucleoparticle assembly and recruitment

L. Saenger, H. M. Williams, D. Yu, D. Vogel, J. Kosinski, M. Rosenthal, C. Uetrecht

This study identifies RNA's role in disassembling NP trimers and forming RNA-bound assemblies, and shows Z protein interaction with NP is pH-dependent.

bioRxiv · Feb 9, 2023Biophysics

Structural insights into viral genome replication by the Severe fever with thrombocytopenia syndrome virus L protein

H. M. Williams, S. R. Thorkelsson, D. Vogel, M. Milewski, C. Busch, S. Cusack, K. Grunewald, E. Quemin, M. Rosenthal

This study presents cryo-EM structures of the SFTSV L protein during genome replication, revealing RNA binding and elongation mechanisms.

Nucleic Acids Research · Jan 18, 2023Peer-reviewedBiochemistry

Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity

T. Kouba, D. Vogel, S. R. Thorkelsson, E. R. J. Quemin, H. M. Williams, M. Milewski, C. Busch, S. Guenther, K. Gruenewald, M. Rosenthal, S. Cusack

This study presents cryo-EM structures of Lassa virus L protein in different states, revealing conformational changes linked to promoter binding and RNA synthesis, and supports antiviral drug development.

bioRxiv · Jun 24, 2021Biochemistry

An inability to maintain the ribonucleoprotein genomic structure is responsible for host detection of negative-sense RNA viruses

D. Blanco-Melo, B. E. Nilsson-Payant, S. Uhl, B. Escudero, S. Olschewski, P. Thibault, M. Panis, M. Rosenthal, C. Munoz-Fontela, B. Lee, B. tenOever

The paper shows that limiting nucleoprotein (NP) in negative-sense RNA viruses leads to defective genomes and triggers host interferon responses, making NP a key antiviral target.

bioRxiv · Mar 12, 2020 · PreprintMicrobiology

Structural and functional characterization of the Severe fever with thrombocytopenia syndrome virus L protein

D. Vogel, S. R. Thorkelsson, E. R. J. Quemin, K. Meier, T. Kouba, N. Gogrefe, C. Busch, S. Reindl, S. Guenther, S. Cusack, K. Gruenewald, M. Rosenthal

This study characterizes the structure and function of the SFTSV L protein using cryo-EM and X-ray crystallography to inform antiviral strategies.

bioRxiv · Mar 2, 2020Biochemistry