Membrane-tethered peptides derived from intracellular loops 2 and 3 of the urotensin II receptor act as allosteric biased ligands
H. Nassour, T. A. Hoang, R. D. Martin, J. C. C. Dallagnol, E. Billard, M. Letourneau, E. Novellino, A. Carotenuto, B. G. Allen, J. C. Tanny, A. Fournier, T. E. Hebert, D. Chatenet
The paper synthesizes and characterizes pepducins from the urotensin II receptor, showing they act as biased allosteric modulators with specific signaling effects.
bioRxiv · Nov 23, 2020Pharmacology & Toxicology