Author

T. E. Hebert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

D. Devost· 2 shared J. C. Tanny· 2 shared R. D. Martin· 2 shared A. Carotenuto· 1 shared A. F. A. Keszei· 1 shared A. Fournier· 1 shared A. K. Shukla· 1 shared A. Ranjan· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBiochemistry

D. Devost

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structure and dynamics of a pentameric KCTD5/Cullin3/Gβγ E3 ubiquitin ligase complex

D. M. Nguyen, D. H. Rath, D. Devost, D. Petrain, R. Rizk, A. X. Ji, N. Narayanan, D. Yong, A. Zhai, D. A. Kuntz, M. U. Q. Mian, N. C. Pomroy, A. F. A. Keszei, S. Benlekbir, M. T. Mazhab-Jafari, , G. G. Prive

The paper presents the cryo-EM structure of a pentameric KCTD5/CUL3/Gβγ E3 ubiquitin ligase complex, revealing its dynamic architecture and mechanism for ubiquitylating Gβγ.

bioRxiv · Sep 20, 2023 · PreprintBiochemistry

Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody

M. Baidya, M. Chaturvedi, H. Dwivedi-Agnihotri, A. Ranjan, D. Devost, Y. Namkung, T. M. Stepniewski, S. Pandey, M. Baruah, B. Panigrahi, J. Maharana, R. Banerjee, J. Selent, S. Laporte, T. E. Hebert, A. K. Shukla

This paper shows that a synthetic intrabody enhances β-arrestin endosomal trafficking and ERK1/2 activation in a GPCR mutant by promoting an active-like conformation.

bioRxiv · Jan 11, 2022Biochemistry

Membrane-tethered peptides derived from intracellular loops 2 and 3 of the urotensin II receptor act as allosteric biased ligands

H. Nassour, T. A. Hoang, R. D. Martin, J. C. C. Dallagnol, E. Billard, M. Letourneau, E. Novellino, A. Carotenuto, B. G. Allen, J. C. Tanny, A. Fournier, T. E. Hebert, D. Chatenet

The paper synthesizes and characterizes pepducins from the urotensin II receptor, showing they act as biased allosteric modulators with specific signaling effects.

bioRxiv · Nov 23, 2020Pharmacology & Toxicology

An interaction between Gβγ and RNA polymerase II regulates transcription in cardiac fibroblasts

S. M. Khan, R. D. Martin, S. Gora, C. Bouazza, J. Jones-Tabah, A. Zhang, S. MacKinnon, P. Trieu, P. B. Clarke, J. C. Tanny, T. E. Hebert

The paper shows Gβγ interacts with RNA polymerase II in cardiac fibroblasts, negatively regulating fibrotic gene expression, with cell-specific signaling pathways involved.

bioRxiv · Mar 13, 2020 · PreprintBiochemistry