Active elimination of intestinal cells drives oncogenic growth in organoids
A. Krotenberg Garcia, A. Fumagalli, H. Quang Le, O. J. Sansom, J. van Rheenen, S. J. Suijkerbuijk
The paper shows cancer cells in organoids eliminate wild-type cells through apoptosis and JNK signaling, promoting their own growth by forcing cell death and fate change in competing cells.
bioRxiv · Nov 14, 2020Cancer Biology