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Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
12 papers
Recent·Most cited
I. Granero-Moya, G. Belthier, B. Groenen, M. Molina, M. Gonzalez, X. Trepat, J. van Rheenen, I. Andreu, P. Roca-Cusachs
The paper shows that nucleocytoplasmic transport (NCT) in cell monolayers responds to mechanical forces but not cell density, contrasting with YAP's response to both mechanics and cell density.
bioRxiv · Jan 11, 2024 · PreprintCell Biology
M. C. van der Net, M. J. Vliem, L. J. S. Kemp, C. Perez-Gonzalez, E. A. Strating, A. Krotenberg-Garcia, R. M. Houtekamer, K. B. van den Anker, J. L. Monster, H. J. G. Snippert, A. A. Khalil, J. van Rheenen, S. J. Suijkerbuijk, O. Kranenburg, D. Matic Vignjevic, M. Gloerich
This study shows that mechanical signals from the Collagen I-rich matrix drive fate transitions in colorectal cancer cells, enabling metastasis despite lacking Lgr5 expression.
bioRxiv · Sep 17, 2023 · PreprintCancer Biology
G. Huelsz-Prince, R. N. U. Kok, Y. J. Goos, L. Bruens, X. Zheng, S. I. J. Ellenbroek, J. van Rheenen, S. J. Tans, J. S. van Zon
The paper tracks cell proliferation in mouse intestinal organoids and shows symmetric proliferative behavior between sister cells minimizes fluctuations.
bioRxiv · Mar 17, 2022Cell Biology
E. Peuhu, G. Jacquemet, C. L. Scheele, A. Isomursu, I. Paatero, K. Thol, M. Georgiadou, C. Guzman, S. Koskinen, A. Laiho, L. L. Elo, P. Boström, P. Hartiala, J. van Rheenen, J. Ivaska
This study shows MYO10 promotes BM assembly in DCIS to limit invasion but facilitates cancer cell dissemination in invasive breast cancer.
bioRxiv · Oct 22, 2021 · PreprintCell Biology
J. V. van Asperen, R. Uceda-Castro, C. Vennin, J. Sluijs, E. J. van Bodegraven, A. S. Margarido, P. Robe, J. van Rheenen, E. M. Hol
This study shows that GFAP splice variants differentially regulate glioma cell migration and invasion, with GFAP{delta} depletion causing random migration and GFAP depletion enabling directional persistence.
bioRxiv · Aug 19, 2021Cell Biology
M. Rossi, G. Doglioni, L. Bornes, D. Broekart, M. Planque, J. Fernandez-Garcia, G. Rinaldi, J. Van Elsen, D. Nittner, C. Jauset, F. Rizzollo, C. Riera Domingo, M. Orth, L. E. Dobrolecki, T. Van Brussel, , S.-M. Fendt
This study identifies PHGDH protein expression heterogeneity as a driver of breast cancer metastasis by altering metabolic pathways and promoting dissemination.
bioRxiv · Jan 24, 2021Cancer Biology
M. L. Tognoli, N. Vlahov, S. Steenbeek, A. M. Grawenda, M. Eyres, D. Cano-Rodriguez, S. Scrace, C. Kartsonaki, A. von Kriegsheim, E. Willms, M. Wood, M. G. Rots, J. van Rheenen, E. O'Neill, D. Pankova
This study shows RASSF1C promotes amoeboid invasion, cancer stemness, and invasive extracellular vesicles through SRC/Rho axis activation in breast cancer.
bioRxiv · Jan 5, 2021Cancer Biology
A. Krotenberg Garcia, A. Fumagalli, H. Quang Le, O. J. Sansom, J. van Rheenen, S. J. Suijkerbuijk
The paper shows cancer cells in organoids eliminate wild-type cells through apoptosis and JNK signaling, promoting their own growth by forcing cell death and fate change in competing cells.
bioRxiv · Nov 14, 2020Cancer Biology
A. M. van der Leun, M. E. Hoekstra, L. Reinalda, C. L. Scheele, M. Toebes, M. J. van de Graaff, H. Li, A. Bercovich, Y. Lubling, E. David, D. S. Thommen, A. Tanay, J. van Rheenen, I. Amit, S. I. van Kasteren, T. N. Schumacher
The paper introduces a photoswitchable tag technology to isolate and analyze live cells from specific regions in complex tissues, enabling spatially defined single-cell RNA sequencing.
bioRxiv · Oct 2, 2020 · PreprintBioengineering
A. Sacchetti, M. Teeuwssen, M. Verhagen, R. Joosten, T. Xu, R. Stabile, B. van der Steen, M. M. Watson, A. Gusinac, W. K. Kim, I. Ubink, H. J. van de Werken, A. Fumagalli, M. Paauwe, J. van Rheenen, , R. Fodde
This study identifies EpCAMlo colon cancer cells with phenotypic plasticity, linking Wnt/β-catenin signaling and EMT activation to metastasis and poor prognosis.
bioRxiv · Jul 24, 2020Cancer Biology
B. Corominas-Murtra, C. L. G. J. Scheele, K. Kishi, S. I. J. Ellenbroek, B. D. Simons, J. van Rheenen, E. Hannezo
The paper develops a stochastic competition model for stem cell niche access and validates it across multiple tissue datasets.
bioRxiv · Feb 12, 2020Biophysics
J. B. Post, N. Hami, J. Lohuis, M. van de Ven, R. de Korte-Grimmerink, C. S. Stangl, E. Stelloo, I. Verlaan, J. van Rheenen, H. J. G. Snippert
This study uses CRISPR to generate CRC organoids with different RAS pathway mutations, revealing distinct drug responses and growth patterns.
bioRxiv · Nov 29, 2019 · PreprintCancer Biology