HuR enhances SARS-CoV-2 non-structural protein translation through the genomic 5'-UTR, by promoting polypyrimidine tract-binding protein binding
H. Raheja, R. Sahu, T. Ghosh, P. Rani, B. George, O. Khatun, S. Tripathi, S. Das
This paper identifies HuR's role in enhancing SARS-CoV-2 non-structural protein translation via the 5'-UTR by promoting PTB binding, while suppressing structural protein translation, and shows potential therapeutic targeting of HuR.
bioRxiv · Mar 15, 2023Microbiology