Loss of tumor suppressor WWOX accelerates pancreatic cancerdevelopment through promotion of TGFβ/BMP2 signaling
H. Husanie, M. Abu-Remaileh, K. Maroun, L. Abu-Tair, H. Safadi, K. Atlan, T. Golan, R. I. Aqeilan
This study shows that loss of WWOX promotes pancreatic cancer by enhancing TGFβ/BMP2 signaling, leading to increased cancer stemness and macrophage infiltration.
bioRxiv · Mar 10, 2022Cancer Biology