M. Abu-Remaileh

This study shows TRPML1 activation reduces lysosomal storage in CLN3-deficient retinal cells but does not restore BMP levels.

The paper identifies MFSD1 as a lysosomal dipeptide uniporter that facilitates the transport of cationic and neutral dipeptides when amino acid exporters are overloaded.

This study uses proteomic profiling to reveal lysosomal heterogeneity and its role in longevity by identifying protein dynamics and interactions in lysosomes.

The paper identifies CYP4F2 as a human-specific genetic determinant of plasma N-acyl amino acid levels and shows its role in metabolic diversification.

This study identifies SPNS1 as a critical lysosomal transporter for choline recycling under limitation, revealing a novel pathway for phospholipid salvage and cell survival.

This paper introduces Golgi-IP, a method to isolate and analyze the human Golgi's proteome, metabolome, and lipidome, revealing novel components and metabolic features.

This study shows that loss of WWOX promotes pancreatic cancer by enhancing TGFβ/BMP2 signaling, leading to increased cancer stemness and macrophage infiltration.

This study identifies the NGLY1/NFE2L1 pathway as a regulator of ferroptosis, showing that NGLY1-mediated deglycosylation of NFE2L1 is necessary for its anti-ferroptotic function through GPX4 expression.

This study identifies RSH-1 as a lysosomal NADPH phosphatase that regulates ER proteostasis via mTOR signaling in C. elegans.

The paper identifies SLC37A3 as a transporter required for nitrogen-containing bisphosphonates (N-BPs) to enter the cytosol, revealing their mechanism of action.