DNA sensor ABCF1 phase separates with cccDNA to inhibit HBV replication
C. Ren, Z. Zhang, Y. Dou, Y. Sun, L. Wang, Z. Fu, K. Wang, C. Gao, Y. Fan, S. Sun, X. Yue, C. Li, L. Gao, X. Liang, Z. Wu, C. Ma
This study identifies ABCF1 as a host protein that interacts with cccDNA, forming phase-separated condensates to suppress HBV replication through innate immune activation and transcription inhibition.
bioRxiv · Dec 21, 2023 · PreprintMicrobiology