Activation of the membrane-bound Nrf1 transcription factor by USP19, a ubiquitinspecific protease C-terminally tail-anchored in the endoplasmic reticulum
H. Shaofan, X. Yuancai, Q. Lu, W. Meng, Y. Zhang
This paper identifies USP19 as a modulator of Nrf1 stability and activity by preventing its ubiquitination and degradation, showing its role in tumor growth regulation.
bioRxiv · Oct 5, 2020Biochemistry